Be Accessible After the Send-off
Emergencies don't take a vacation -- even if you're on one.
If you'll be honeymooning (and this is doubly important if you're traveling outside the country), draft a detailed itinerary with your emergency numbers and hotel and flight information. Give it to a trusted friend or parent in case they need to contact you, and be sure to let others know who has the information. This is particularly critical if you have pets or children back at home that might require sudden medical attention.
It's also a good idea to check in every couple of days by e-mail or phone in case any surprises have popped up in your absence.