One thing you don’t want to have when applying for jobs is a giant gap of time on your resume that looks like you weren't doing anything (even though you and every other parent knows you’ve really been working full time the whole time!). Think about any volunteer work you’ve done for your kids' school, your church, or any other organization you’ve helped in recent months or years, and add that work to your resume. No matter what it was, it undeniably required some sort of skill set – skills you should try to list out if you can – and shows that you’ve been an active participant in making something happen.
Depending on how long you’ve been out of the workforce, there may have been a little or a lot of advancement in the technology or general practice in your field. Take a computer class or other class in your field to show that you’ve put effort into staying up to date with the latest advancements in your field.