Your first line of defense in party cleanup is planning for the big event.
Hours before the first guests arrive, you're going to have to think like you're 4 feet tall and strung out on birthday cake and high spirits. Everything fragile that's within reach of little hands needs to be moved, as well as every bottle of poisonous cleanser -- there's no way that you can count on other people's kids having as much common sense as your own.
Basically anything that flows, shatters, spreads, stains or scatters should be out of reach of anyone who can't legally vote yet. Half an hour spent scanning the house at a kid's eye level can save hours of cleaning (and maybe even a few of your tears) later on.